COMP ELISA Kit for Bovine(Bos taurus) | EIAab.comCOMP ELISA Kit for Bovine(Bos taurus)

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COMP (Gene name),

Cartilage oligomeric matrix protein (Protein name ), COMP_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

COMP;

Protein name:

Cartilage oligomeric matrix protein(COMP);

Alternative:

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Pentamer; disulfide-linked. Exists in a more compact conformation in the presence of calcium and shows a more extended conformation in the absence of calcium. Interacts with ITGB3, ITGA5 and FN1. Binding to FN1 requires the presence of divalent cations (Ca(2+), Mg(2+) or Mn(2+)). The greatest amount of binding is seen in the presence of Mn(2+). Interacts with MATN3, MATN4 and ACAN. Binds heparin, heparan sulfate and chondroitin sulfate. EDTA dimishes significantly its binding to ACAN and abolishes its binding to MATN3, MATN4 and chondroitin sulfate. Interacts with collagen I, II and IX and interaction with these collagens is dependent on the presence of zinc ions (By similarity). Interacts with MATN1. Interacts with ADAMTS12. Interacts with ITGA7.

Function:

May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.

Subcellular Location:

Secreted extracellular space extracellular matrix

Protein Attributes:

Sequence length:

756

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

756:

QRLLQA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Bt.3034

SMR:

P35445

Pfam:

PF11598

STRING:

9913.ENSBTAP00000006074

String:

P35445

Uniprot:

P35445

FOR

ELISA Kit for Bovine COMP

Cat.:

E1197h

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Packing:

96T

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ELISA Kit for Bovine COMP

Cat.:

E1197m

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Packing:

96T

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ELISA Kit for Bovine COMP

Cat.:

E1197r

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96T

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ELISA Kit for Bovine COMP

Cat.:

E1197b

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Packing:

96T

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CLIA Kit for Bovine COMP

Cat.:

U1197r

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Bovine COMP

Cat.:

U1197m

Price:

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Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Bovine COMP

Cat.:

U1197h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Bovine COMP

Cat.:

U1197b

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MSDS:

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Packing:

96T

Polyclonal Antibody for Bovine COMP

Cat.:

P1197Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Bovine COMP

Cat.:

P1197Rb-r

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Bovine COMP

Cat.:

P1197Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Bovine COMP

Protein for Bovine COMP

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The genome sequence of taurine cattle: a window to ruminant biology and evolution."
The bovine genome sequencing and analysis consortium
Science324:522-528(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: Hereford.
2.

"COMP (cartilage oligomeric matrix protein) is structurally related to the thrombospondins."
Oldberg A. , Antonsson P. , Lindblom K. , Heinegaard D.
J. Biol. Chem.267:22346-22350(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 318-756
tissue: Cartilage.
3.

"Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias."
Mann H.H. , Oezbek S. , Engel J. , Paulsson M. , Wagener R.
J. Biol. Chem.279:25294-25298(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MATN1

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